Cancer
Illumination™ Imaging

Experience the next generation of intraoperative cancer visualization with the Synergy Vision™ imaging system, now cleared for use with CYTALUX® (pafolacianine) injection—an FDA-approved cancer imaging agent.

What Is Cancer Illumination Technology?

Cancer Illumination imaging provides real-time visualization of malignant tissue. Using targeted fluorescent agents and near-infrared (NIR) imaging, the unique technology enables surgeons to identify and remove cancerous lesions in the lungs and ovaries.

Fluorescent agents bind to cancer-specific receptors and emit a signal under NIR light, causing tumors to “light up” during surgery. This illumination allows for clear differentiation between healthy and cancerous tissue, improved detection1 of small or hidden lesions, and enhanced visibility of tumor margins.

Applications in Lung and Ovarian Cancer

Cancer Illumination imaging has proven especially valuable in thoracic and gynecologic oncology. It helps uncover lesions that may not be visible on preoperative imaging and assists in guiding more confident resections, even in anatomically challenging areas.

How Cancer Illumination Works

01

IV Administration

Administer CYTALUX intravenously to patients before surgery.

02

Allow for Circulation

Perform surgery between 1 and 24 hours after IV administration for lung cancer procedures, and between 1 and 9 hours after IV administration for ovarian cancer procedures.

03

Allow CYTALUX to Work

CYTALUX contains a folic acid analog that binds to folate receptors present on lung and ovarian cancer cells.

04

Perform Procedure With Synergy Vision System

Use the Synergy Visionary™ camera head in NIR mode to visualize CYTALUX to detect where cancerous cells exist.

Cancer Illumination imaging has proven especially valuable in thoracic and gynecologic oncology. It may help uncover lesions that may not be visible on preoperative imaging and assists in guiding more resections, even in anatomically challenging areas.

With Cancer Illumination
With Cancer Illumination
Without Cancer Illumination
Without Cancer Illumination

Applications in
Lung and Ovarian Cancer

Why Accurate
Cancer Detection Matters

Surgeons using Cancer Illumination Imaging

Surgeons using Cancer Illumination imaging benefit from:

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    Greater surgical precision with fewer missed lesions1

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    Improved margin assessment, reducing residual disease1

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    Possible lower recurrence rates through more complete tumor removal1

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    Real-time decision support during complex procedures

Incomplete removal of cancerous lesions is a leading cause of cancer recurrence.2 Cancer Illumination imaging improves the visibility and detection of malignant tissue, helping surgeons achieve improved margins.1

Explore Our Cancer Illumination System

The Synergy Vision imaging system is an all-in-one console that offers visualization for endoscopic and open surgery, with near-infrared fluorescence and cancer illumination imaging modalities.

Synergy Vision imaging system

Proven Results

Cancer Illumination imaging is supported by clinical trials in both lung and ovarian cancer diagnoses. Surgical oncology studies show improvements in cancerous lesion detection, closer margins, and more.1

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19%

27%

With CYTALUX, additional lesions were found in 27% of patients.3
8%

8%

In 8% of patients, surgeons found one or more additional cancerous lesions that were not previously identified.1
38%

19%

19% of patients had lesions that their surgeon could not detect without the use of CYTALUX.1
19%
Surgeons reported changing the scope of their procedure based on the insight provided by CYTALUX in 29% of patients.1
38%
In 38% of patients, CYTALUX helped surgeons discover a “close resection margin”.1

What is Synergy?

The Synergy product portfolio is a comprehensive set of interconnected surgical tools and technology for the operating room. Our award-winning imaging system is comprised of 4K cameras and monitors and video and data integration. The integrated surgical devices include soft-tissue and bone resection, fluid management, and insufflation.

The Synergy Product Portfolio

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Surgeons in the operating room

4K Imaging

See how our imaging system delivers a new level of visualization and optimization to your surgical area.

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Surgeon working in the operating room

Endoscopy

Synergy has imaging and workflow management solutions for endoscopy.

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Surgeon working in the operating room

Arthroscopy

Our complete line of electromechanical resection, radiofrequency ablation, fluid management devices, and battery-powered hand instruments helps meet all your arthroscopic needs.

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Surgeons in the operating room

OR Integration

Our video and data integration solutions seamlessly integrate with your existing EHR and OR equipment.

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Surgeon sharing information with a patient

Patient Engagement

Our surgeon-patient communication tools can help improve your patient's experience.

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Support specialist examining a product

Service and Support

Real-time remote diagnosis ensures maximum reliability and OR use.

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Interested in learning how Cancer Illumination technology can support your surgical or clinical goals?

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